In a recent study published within the Journal of Medical Virology, researchers analyzed antibody profiles of moms infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and their offspring.

Study: SARS-CoV-2 IgG “heritage” in newborn: a credit of maternal natural infection. Image Credit: Corona Borealis Studio/Shutterstock

Background

Neonates born to SARS-CoV-2-infected moms rarely contract the virus. A scientific review involving over 1100 pregnant women with coronavirus disease 2019 (COVID-19) and 985 neonates observed a low rate (0.3%) of neonatal infection. Vertical transmission of SARS-CoV-2 could occur via 1) transplacental transfer of the virus to the fetus or 2) vaginal fluids during delivery. Passive immunity could protect neonates born to infected moms from infection.

In regards to the study

In the current study, researchers examined the anti-SARS-CoV-2 antibody profiles of infected moms and their children. This retrospective cohort evaluation included women positive for SARS-CoV-2 while pregnant or at delivery admitted to Santo Stefano Hospital in Italy and their neonates between March 2020 and January 2022. Polymerase chain response (PCR) tests were performed on nasopharyngeal swab samples during universal screening on admission to the delivery unit.

At delivery, all SARS-CoV-2-positive women and their neonates were screened for anti-spike IgM and IgG antibodies. SARS-CoV-2 PCR tests were also performed on newborns a day after birth. Electronic medical records were accessed to acquire information on age, delivery type, COVID-19 symptoms and severity, the time between positive test and delivery, neonatal PCR data, and maternal and neonatal serologic status.

Findings

Through the study period, 269 SARS-CoV-2-positive females delivered to the hospital. Data on serum anti-spike IgG and IgM antibodies were available for 143 mother-neonate dyads, who were included for evaluation, while the remaining individuals were excluded resulting from an absence of complete data.

Thirteen pregnant women (group 1) were positive for the virus at delivery, 85 (group 2) were positive one to seven days before delivery, 23 (group 3) were positive 8-to-14 days before delivery, and 22 (group 4) tested positive 14-to-195 days before delivery. Maternal rates of anti-spike IgG seropositivity increased with time since infection at delivery.

In group 1, three moms and two neonates were positive for anti-spike IgG antibodies. Within the second group, 27 females and 22 newborns exhibited IgG positivity. Fourteen women and eight neonates from group 3 had IgG antibodies. Nineteen women and 16 newborns from group 4 developed IgG antibodies. There have been five IgG-positive neonates born to IgG-negative moms.

Anti-spike IgM antibodies were detected in 25 women; two from group 1, 11 from group 2, seven from group 3, and five from group 4. Two neonates were IgM-positive; one was born to a seronegative mother who tested SARS-CoV-2-positive at delivery. The second neonate was seropositive for each IgM and IgG antibodies and was born to an IgM- and IgG-positive mother diagnosed with COVID-19 two weeks before delivery.

Overall, 10 newborns tested SARS-CoV-2-positive at day one in every of life and had a low viral load. Eight were seronegative, and two were IgG-positive but IgM-negative. Seven moms were seronegative for each IgM and IgG; three were IgG-positive but IgM-negative. All SARS-CoV-2-positive neonates underwent a second PCR test after 24 to 48 hours, and just one was positive on the retest.

Conclusions

In summary, the authors found higher maternal anti-spike IgG seropositivity because the time between COVID-19 diagnosis and delivery increased. Notably, IgM antibodies were detected in two newborns who were SARS-CoV-2-negative at birth. That is unusual, on condition that IgM just isn’t transferred to the fetus resulting from its larger macromolecular size, and SARS-CoV-2-associated vascular damage to the placenta could possibly be a plausible explanation.

Overall, the findings reaffirm that seroconversion for SARS-CoV-2-positive pregnant women occurs with similar kinetics as in the overall population, and IgG antibodies are transferred across the placenta to the offspring. Future studies must ascertain the sturdiness of the passively transferred IgG and determine the protection conferred by each maternal infection and vaccination.