Researchers at Karolinska Institutet have created a latest approach to studying the smallest bioparticles within the body. The study, which is published in Nature Biotechnology, has considerable scientific potential, equivalent to in the event of simpler vaccines.

Circulating across the body are nanoparticles that affect it in a method or one other. For instance, there are lipoproteins that maintain cell metabolism, pathogenic viruses that cause many diseases and lipid nanoparticles which can be used to hold drugs, like recent lipid nanoparticle-based mRNA vaccines.

Nonetheless, such particles are too small to be studied easily. To enable this, the researchers on this study have developed a latest method that they call single-particle profiling (SPP).

We’re presenting a latest method that offers unprecedented details about nano-sized particles.”

Erdinc Sezgin, study’s last creator, assistant professor, SciLifeLab and the Department of Women’s and Kid’s Health, Karolinska Institutet

The strategy makes it possible to measure the content and properties of hundreds of particles between 5 and 200 nanometres in size.

“Our method may be used to review bioparticles in health and disease.” says Dr Sezgin. “Furthermore, it is going to even be a useful tool in creating higher and simpler nanocarriers.”

Considered one of the researchers’ goals was to create an easy, inexpensive method accessible to all researchers.

“We established a technique based on commercially available microscopes and made our data-analysis tool and all our data freely available,” says Dr Sezgin.

Source:

Journal reference:

Sych, T., et al. (2023). High-throughput measurement of the content and properties of nano-sized bioparticles with single-particle profiler. Nature Biotechnology. doi.org/10.1038/s41587-023-01825-5