Reducing weight and maintaining weight reduction is at all times difficult for individuals with obesity. A recent study explained how the brain responses in chubby people function otherwise in response to sugar and fat, making weight reduction a tricky journey.

The findings of the study, published within the journal Nature Metabolism, explained how obesity caused the brain to lose alignment with what was happening within the gut.

“Our interpretation is, there is a generally reduced nutrient-sensing in individuals with obesity. It could help explain why weight reduction and weight-loss maintenance are so hard,” senior researcher Dr. Mireille Serlie said.

The study evaluated 30 adults with a healthy body weight and 30 with obesity. The brain responses of the participants to sugar and fat were captured after the nutrients were delivered on to the gut.

The lean participants showed specific patterns of brain activity when the nutrients were delivered, while these were “severely impaired” in obese people. The participants who were chubby also had a lesser release of dopamine from the striatum of the brain liable for regulating eating habits.

Even after shedding 10% of their weight on a reduced-calorie weight-reduction plan for 3 months, the brain responses of the obese participants didn’t reverse.

Researchers consider that impaired nutrient signaling just isn’t everlasting and will be regained with more time and sustained weight reduction.

Earlier experiments on lab animals indicated the brain responded to the presence of nutrients within the gut even without the sensory experience of eating.

“The step forward on this study is that they are showing this is occurring in humans, too, however the response is totally blunted in individuals with obesity,” Alexandra DiFeliceantonio, a co-author of the study, said.

The nutrient signaling between the gut and the brain helps people select what they eat, however the signaling is “broken ultimately” attributable to obesity, DiFeliceantonio added.

Meanwhile, the researchers couldn’t determine when precisely the signaling becomes impaired or how.

Based on the study, the key to lasting weight reduction just isn’t at all times in regards to the “willpower” to proceed the weight-reduction plan, as obese individuals are continuously fighting not only the temptations of low-cost, available junk food, but in addition a “hungry brain” that makes weight-reduction plan changes and weight reduction difficult.

“I do think people get blamed. This just isn’t about willpower. It’s an actual struggle. And we’re starting to know why people struggle,” Serlie said.

Nevertheless, through weight-reduction plan, lifestyle changes, and medications the researchers hope to seek out a solution to correct the nutrient signaling in the longer term.

A recent study explains how the brain responses in chubby people function otherwise in response to sugar and fat, making weight reduction a tricky journey.
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Published by Medicaldaily.com