A recent research paper was published in Genes & Cancer on November 23, 2022, entitled, “Ectopic expression of lncRNA MVIH as a possible diagnostic biomarker in cervical cancer.”
Cervical cancer (CC) is probably the most common cancers in women. Recent advances in screening and vaccination against the papilloma virus (HPV) have increased protection against CC. Nevertheless, there isn’t a effective diagnostic biomarker and treatment approach throughout the course of the disease.
On this recent study, researchers Mohammad Ghanbari, Aida Aghazadeh, Elaheh Malekabbaslou, Ali Rajabi, Aref Sobhkhizy, Melika Maydanchi, Ali Saber, and Reza Safaralizadeh from the University of Tabriz and Zimagene Medical Genetics Laboratory aimed to guage the changes within the expression of lncRNA related to microvascular invasion in hepatocellular carcinoma (lncRNA MVIH) and its diagnostic value as a biomarker in CC patients.
“This research is aimed to guage the expression levels of MVIH in CC tumors to evaluate the potential of this lncRNA as a diagnostic biomarker in CC patients.”
One-hundred and fifteen (n = 115) pairs of CC primary tumor and marginal non-tumor tissue samples were obtained from Tabriz Valiasr International Hospital (Tabriz, Iran). RNA extraction and cDNA synthesis followed by quantitative reverse transcriptase PCR (qRT-PCR) were considered to research alterations within the expression levels of MVIH in patients with CC. The associations between MVIH expression changes and clinicopathological features in addition to its potential as a diagnostic biomarker were assessed using SPSS and GraphPad prism software and the receiver operating characteristic (ROC).
The expression levels of MVIH were significantly higher in CC tumors as in comparison with marginal non-tumor samples (p < 0.0001). Overexpression of MVIH was significantly related to younger age (p = 0.033), lymph node metastasis (p = 0.031), tumor invasion depth (p = 0.035), and squamous cell style of CC (p = 0.019). The ROC evaluation for MVIH as a diagnostic biomarker revealed the respective sensitivity and specificity of 67.83 and 80.
“Overexpression of MVIH in CC tumors suggests its oncogenic role during tumorigenesis. Thus, it could function a possible diagnostic biomarker.”
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Journal reference:
Ghanbari, M., et al. (2022) Ectopic expression of lncRNA MVIH as a possible diagnostic biomarker in cervical cancer. Genes & Cancer. doi.org/10.18632/genesandcancer.224.